One of my g-g-g-grandmothers was Martha Holmes, of Donaghmore Parish, Co. Donegal; and my g-grandmother was born Martha Holmes Wray (named after her grandmother).
A Holmes relative, Nick Holmes, has done extensive genealogy work on this Holmes family, as well as inter-related families (Wray, Stewart, McCurdy, etc.).
There is still a very small area called "Holmestown", not far from Castlefinn, where our original Holmes progenitor settled. All the Holmes families in that area of Donegtal are said to originate from this one original settler, Robert Holmes, who emigrated from the Isle of Wight to Co. Donegal in 1654-55.
I am attaching a link to Nick's page where he explains about Robert Holmes' arrival in Donaghmore, Donegal, etc.:
https://holmes.org.nz/family.php?tree_id=1&id=F0613&main_person=I1989
If your ancestor was, indeed, related to mine (and it appears to be very possible), then we are 'cousins', albeit distant!
...Lynne