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There is no way to know if the Edward Campbell record belongs to your Edward. I did not locate the 1821 census record you mentioned.
Hugh Clarke married Catherine Reilly in July 1908 https://civilrecords.irishgenealogy.ie/churchrecords/images/marriage_returns/marriages_1908/10065/5660952.pdf
Here is the family in the 1911 census http://www.census.nationalarchives.ie/pages/1911/Leitrim/Carrigallen_East/Drumkeelwick/658240/ They lived in Drumkeelrick
Civil birth records for children